FANTAB Research

Research Questions that have been suggested by reviewers and critics
regarding the finding of fMRI hyperfrontality and hypoconnectivity in NFL alumni:

1) Could it [the fMRI finding] be caused by something else, such as steroid, drug or alcohol abuse?
2) Does it change over time in relation to injury: pre-post, immediate-delayed, or repetitive?
3) Is it affected by injury severity?
4) Is it also abnormal in Alzheimer's and other non-traumatic dementias, and if so does it progress over time?

Research plan: To address these and other questions we will test additional normal subjects, both student athletes before their first head injury, and older persons before any symptoms of cognitive impairment; then re-test them over time, both after injury and after the appearance of symptoms.

The FANTAB test has been optimized, there is already a database of normal subjects and the test will be available at many MRI centers across the country. Thus, FANTAB testing can be incorporated in research protocols more cost-effectively and more conveniently for subjects, then can studies done in university fMRI departments using experimental methods.

In addition, our recently published paper presented our results only for the Tower-of-London task, we will soon be publishing our results on the other tasks in the battery including the Stroop, go-no go, paired-associate learning, and memory.


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